You never go full Meta.
The ending, such as it was, is perfectly reconcilable. The blood obviously didn’t work on Todd since he’s a moron and doesn’t have the unique Banner genetics. Hulk didn’t show up. Blonski realized he was hurting Jen (and violating parole) and her friend called Damage Control. The wallbreak was basically set dressing. I *do* figure it’s pretty likely Leader has (or obtains) Jen’s blood and he *is* smart enough to use it. Cheets had an interesting idea that Hulk, Skarr, and possibly Daredevil at the end are Skrulls which I could see being the case.