The original pilot focused on people working at an insurance company dealing with the fallout of superhero/supervillain clashes. After an internal shakeup, the show has changed to be focused on a division of Wayne Enterprises that develops essentially "As Seen On TV"-style gadgets designed to protect civilians DURING these clashes.
Meanwhile, Alan Tudyk's (Firefly, Suburbia, Rogue One) has been revamped since the original pilot to be Bruce Wayne's cousin.
The show also stars Vanessa Hudgens (High School Musical, High School Musical 2, High School Musical 3, and the probably inevitable High School Reunion Musical), Ron Funches, and Danny Pudi (Community).
The zany action starts Thursday, February 2, at 8:30 on NBC.
Unlike Constantine, I'm betting that there is no way to fold this into the Arrow-verse (or even Gotham), but maybe there's room for multiverse crossover cameos at some point.