I always felt bad for the one gal, dying of thirst out in the desert because she felt it would bring her closer to God.
Pretty much every Stranger mission was "terrible thing happens to a crazy person in five steps."
On subsequent playthroughs I would hog tie her and take her the Armadillo Doctor's office. She'd respawn back out in the desert afterwards but at least I tried.
Also low honor turning the greet button into an insult button was wonderful.
Red Dead Redemption is a masterpiece that flies in the face of conventional Rockstar developing (I still love the fact that you can't engage the Prostitutes at all, given you are a married man...but you can hog tie said Prostitute and strap her to train tracks for a gruesome death) and was just an amazing game.
Got it as a wedding gift, actually. I spent a entire night - TWELVE HOURS - playing Poker. Not the game, just POKER.
Poker and Liar's Dice were pretty legit.