I'd use the NetFlix Voltron show as an example of what I would want to do. Energetic anime-style art and direction done in the west, in a series that aims to give a tried and true franchise a bit of a face lift. I'd also point to Animated, as an example of the "fresh" tone I'd want to go for.
Setup. The War's more or less over. The Cybertronian Commonwealth (Cybertron and the colonies) have been overwhelmed by the Decepticons. Sentinel Prime leads the remnants of the Autobot military and civilians fleeing Decepticon tyranny on an exodus. Sentinel's flagship, the mighty Ark, holds the line as the various ships of the Autobot fleet jump away to a secret point in far space, where they should be safe from Decepticon expansion for the time being. Megatron, meanwhile, wants his fleet to eliminate as many Autobots as possible so he can finish this war once and for all.
Megs' flagship, the Nemesis, attacks the Ark directly. Megatron leads a boarding party onto the Ark, just as the last Autobot ship jumps away. Megatron and Sentinel fight one on one, and Megs beats the Autobot leader down. He would have finished him and claimed the Matrix, if not for Sentinel's protege, Orion Pax. Pax distracts Megatron long enough for Ironhide and Jetfire to lead a counterattack to drive the Decepticons off the Ark.
Nav systems are damaged, and they're unable to lock on to the secret jump point. They have to make a blind jump, or else the Decepticon fleet will annihilate them. Orion takes command as Sentinel begins to succumb to his wounds, and the Autobot flagship jumps, appearing behind the Earth's moon.
Ratchet tends to Sentinel, but the Prime isn't going to make it. He passes the Matrix to Orion, who insists he's not worthy. Sentinel merely tells him that fate rarely calls upon you on a moment of your choosing, and passes on to the AllSpark. Orion reluctantly accepts the Matrix, and becomes Optimus Prime.
Optimus now needs to settle what Autobots he has left aboard the Ark on Earth, and attempt to reconnect with the rest of the Autobot fleet (who are unaware of what's happened with the Ark and her crew). He needs to learn how to lead his scattered people in the darkest of times, as well as adapt to life on Earth.
The Decepticons, meanwhile, are scouring the galaxy for the Autobots. The Matrix Flame on Caminus expired and relit, so the 'Cons know that Sentinel is dead and that there's a new Prime. Megs wants him found and crushed before he can rally the Autobots. One of his scout teams, lead by Starscream, arrives on Earth and discovers the Autobots. The Autobots are able to destroy Starscream's team's communications relay, but they now have to content with a team of battle hardened Decepticons who now threaten their new refuge.
Season one would focus on the fight against Starscream and his team. It would end with Starscream's plans to conquer Earth defeated, yet he's still able to send a single into deep space. Megs gets it, and he's coming to Earth with an army.
Season two would focus on Megatron bringing the war to Earth. Optimus and co. would have been building connections with the humans through season one, and now he needs to rally them to stand with his Autobots to defend the planet. Things look dire until the last few episodes, when Ultra Magnus, Springer, and Star Sabre arrive, bringing the rest of the Autobot fleet with them. Season ends with a huge battle above and on Earth that sees the 'Cons defeated.
Season three picks up with the Autobots about to return to the Cybertronian Commonwealth in victory. But then a new threat emerges. An old Prime, long thought dead, returns. Nova Prime and his right hand man Jhiaxus were thought lost millions upon millions of years back, when their exploratory expedition went missing. It was assumed they were dead, but in reality they were lost in the Dead Universe, an empty void parallel to the universe we know. There their forces slowly went mad, and Nova and Jhiaxus formed what they called the Cybertronian Empire. Now they've found a way to cross back into the living universe, and Nova is disgusted by what he sees. Decepticon malcontents and weakened Autobots collaborating with lesser lifeforms. Yes, Nova will reclaim the Cybertronian Commonwealth, but first he needs to deal with Earth. And this weak-minded Prime who calls himself Optimus.
The season will end with Nova's death and Optimus ushering in a new age of peace for both Cybertronians and humans.
Jhiaxus still got away though. He retreated with a portion of the Cybertronian Empire. Now he and Sideways plot in the shadow of a large, ringed, metallic planet. There's peace now, among Cybertronians and humans. But for how long?