To be honest with myself, many of the titles I read are niche and only interest me because I'm a fan of the property (Sonic, Mega Man, Adventure Time). I think they are all genuinely good to GREAT comics, but someone who doesn't have a predisposed affinity for those franchises won't get the same thing out of them.
However, there are a few monthlies I read that I'd highly recommend:
IDW's Ghostbusters. I imagine you've seen the movies, maybe even played the Video Game. Even if you haven't done that last one, you're still in good shape to grab this ongoing from issue #1 and follow it without much of a problem. It is incredibly sharp and clever, the stories are wonderfully paced (not drawn out serialization, but each issue works as a complete story that furthers an ongoing narrative) and the art by Dan Schoening is so packed full of Easter eggs that you'll spend half an hour looking over each panel to try and spot EVERYTHING. You also get tons of bonus material int he form of character and monster files and sketch galleries AND fan art from modern preschoolers which is adorable.
It is the only book out there that costs $3.99 an issue and gives you your money's worth. If you have even the slightest interest in Ghostbusters, it is something to pick up.
The only Big Two title I'm currently reading is Swamp Thing. The story requires a bit of knowledge of the character, but I don't think it's too offputting. The story is enthralling, but really, the ART is what keeps me coming back. I can't believe art this detailed and involved with truly innovative and luxurious layouts on every page can come out monthly. And without delay. I remember reading Astonishing X-Men and The Ultimates and being so annoyed with the artist delays; those books were practically quarterly.
If you're into black and white horror comics, Dark Horse's revival of Creepy has been the best anthology horror book on the market, hands down. It's quarterly, but each issue is stuffed with great content.
Also, Boom's Hellraiser has been GREAT. You only need to be familiar with the first two movies, but this has been some superbly dark and weird reading.
As for IDW's TMNT book, well, I'll be honest that it's probably, from an unbiased view point, "okay". It's got good art and it's doing a lot of innovative things with the characters and their various mythologies, but the Bendis-style of ultra decompressed pacing makes it somewhat tedious to read. IDW's trade strategy isn't helping; 4 issues per volume and they're releasing the microseries issues, which are required reading, in seperate trades without chronolgy indication as to where they slot in... confusing matters.
You'd be better off waiting for IDW's inevitable "omnibus" trade where they publish everything in proper order and you get more material for less money.
Edited by DrSpengler, 18 April 2012 - 07:36 PM.